Recently published in Gastroenterology: Results of an international study on monitoring guidelines for patients with Lynch Syndrome.
In the international study, patients with Lynch syndrome who have a significantly increased risk of developing colon cancer were examined. To date, there is no international consensus on the recommended time periods for colonoscopic monitoring of patients. Scientists from the German HNPCC Consortium, the Dutch Lynch Syndrome Collaborative Group, and the Finnish Lynch Syndrome Registry investigated which intervals could be beneficial for patients. Interval guidelines were compared in three countries: Germany (patients are examined annually), the Netherlands (patients are examined every 1-2 years), and Finland (patients are examined every 2-3 years). The cumulative colorectal cancer incidence and also the colorectal cancer stage showed no significant differences in the investigations between countries.
The results of the study have now been published in the journal Gastroenterology:
Engel C, Vases HF, Seppälä T, Aretz S, Bigirwamungu-Bargeman M, de Boer SY, Bucksch K, Büttner R, Holinski E, Holzapfel S, Hüneburg R, Jacobs MAJM, Järvinen H, Kloor M, von Knebel Doeberitz M, Koornstra JJ, van Kouwen M, Langers AM, van de Meeberg PC, Morak M, Möslein G, Nagengast FM, Pylvänäinen K, Rahner N, Renkonen-Sinisalo L, Sanduleanu S, Schackert HK, Schmiegel W, Schulmann K, Steinke-Lange V, Strasbourg CP, Vecht J, Verhulst ML, de Vos Tot Nederveen Cappel W, Zachariae S, Mecklin JP, Loeffler M; German HNPCC Consortium, the Dutch Lynch Syndrome Collaborative Group, and the Finnish Lynch Syndrome Registry.
Gastroenterology. 2018 Nov;155(5):1400-1409.e2. doi: 10.1053/y.gastro.2018.07.030.
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